Rare Rheumatology News
Advertisement
Disease Profile
Acromegaly
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
1-9 / 100 000
Age of onset
Elderly
ICD-10
E22.0
Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Not applicable
Other names (AKA)
Somatotroph adenoma; Growth hormone excess; Pituitary giant
Categories
Endocrine Diseases; Female Reproductive Diseases; Metabolic disorders;
Summary
Acromegaly is a hormonal disorder that results from the pituitary gland producing too much growth
Acromegaly may also be part of other genetic
Symptoms
This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
Medical Terms | Other Names |
Learn More:
HPO ID
|
|
---|---|---|---|
80%-99% of people have these symptoms | |||
Anterior hypopituitarism | 0000830 | ||
Arthralgia |
Joint pain
|
0002829 | |
Broad foot |
Broad feet
Wide foot
[ more ] |
0001769 | |
Broad forehead |
Increased width of the forehead
Wide forehead
[ more ] |
0000337 | |
Coarse facial features |
Coarse facial appearance
|
0000280 | |
Cortical diaphyseal thickening of the upper limbs | 0003859 | ||
Deep palmar crease |
Deep palm line
|
0006191 | |
Deep plantar creases |
Deep wrinkles in soles of feet
|
0001869 | |
Fatigue |
Tired
Tiredness
[ more ] |
0012378 | |
Full cheeks |
Apple cheeks
Big cheeks
Increased size of cheeks
Large cheeks
[ more ] |
0000293 | |
Growth hormone excess | 0000845 | ||
Hyperhidrosis |
Excessive sweating
Increased sweating
Profuse sweating
Sweating
Sweating profusely
Sweating, increased
[ more ] |
0000975 | |
Joint swelling | 0001386 | ||
Large hands |
large hand
|
0001176 | |
Long face |
Elongation of face
Increased height of face
Increased length of face
Vertical elongation of face
Vertical enlargement of face
Vertical overgrowth of face
[ more ] |
0000276 | |
Long penis |
Enlarged penis
|
0000040 | |
Macrodactyly |
Finger overgrowth
|
0004099 | |
Macroglossia |
Abnormally large tongue
Increased size of tongue
Large tongue
[ more ] |
0000158 | |
Macrotia |
Large ears
|
0000400 | |
Mandibular prognathia |
Big lower jaw
Increased projection of lower jaw
Increased size of lower jaw
Large lower jaw
Prominent chin
Prominent lower jaw
[ more ] |
0000303 | |
Osteoarthritis |
Degenerative joint disease
|
0002758 | |
Pituitary growth hormone |
0011760 | ||
Tall stature |
Increased body height
|
0000098 | |
Tapered finger |
Tapered fingertips
Tapering fingers
[ more ] |
0001182 | |
Thick lower lip vermilion |
Increased volume of lower lip
Plump lower lip
Prominent lower lip
[ more ] |
0000179 | |
Wide nose |
Broad nose
Increased breadth of nose
Increased nasal breadth
Increased nasal width
Increased width of nose
[ more ] |
0000445 | |
30%-79% of people have these symptoms | |||
Abnormal fingernail morphology |
Abnormal fingernails
Abnormality of the fingernails
[ more ] |
0001231 | |
Abnormal toenail morphology |
Abnormality of the toenail
Abnormality of the toenails
[ more ] |
0008388 | |
Anxiety |
Excessive, persistent worry and fear
|
0000739 | |
Broad jaw |
Broad lower face
Wide jaw
[ more ] |
0012802 | |
Cerebral palsy | 0100021 | ||
Depressivity |
Depression
|
0000716 | |
0000819 | |||
Dysmenorrhea |
Painful menstruation
|
0100607 | |
Frontal bossing | 0002007 | ||
Generalized hirsutism |
Excessive hairiness over body
|
0002230 | |
Hoarse voice |
Hoarseness
Husky voice
[ more ] |
0001609 | |
0000822 | |||
Hypogonadotropic |
0000044 | ||
Kyphosis |
Hunched back
Round back
[ more ] |
0002808 | |
Migraine |
Intermittent migraine headaches
Migraine headache
Migraine headaches
[ more ] |
0002076 | |
Palpebral edema |
Fullness of eyelids
Puffy eyelids
Puffy lids
Swelling of eyelids
[ more ] |
0100540 | |
Paresthesia |
Pins and needles feeling
Tingling
[ more ] |
0003401 | |
Sleep apnea |
Pauses in breathing while sleeping
|
0010535 | |
Spinal canal stenosis |
Narrow spinal canal
|
0003416 | |
Synophrys |
Monobrow
Unibrow
[ more ] |
0000664 | |
Widely spaced teeth |
Wide-spaced teeth
Widely-spaced teeth
[ more ] |
0000687 | |
5%-29% of people have these symptoms | |||
Darkened and thickened skin
|
0000956 | ||
Acne | 0001061 | ||
Dysuria |
Painful or difficult urination
|
0100518 | |
Galactorrhea |
Spontaneous milk flow from breast
|
0100829 | |
Generalized hyperpigmentation | 0007440 | ||
Hypersomnia |
Excessive sleepiness
|
0100786 | |
Hypertrophic |
Enlarged and thickened heart muscle
|
0001639 | |
Difficulty getting a full erection
Difficulty getting an erection
[ more ] |
0000802 | ||
Mitral regurgitation | 0001653 | ||
Pituitary prolactin cell adenoma | 0006767 | ||
Wide penis |
TreatmentFDA-Approved TreatmentsThe medication(s) listed below have been approved by the Food and Drug Administration (FDA) as orphan products for treatment of this condition. Learn more orphan products.
Related diseasesRelated diseases are conditions that have similar signs and symptoms. A health care provider may consider these conditions in the table below when making a diagnosis. Please note that the table may not include all the possible conditions related to this disease.
OrganizationsSupport and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD. Organizations Supporting this Disease
Social Networking Websites
Learn moreThese resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional. Where to Start
In-Depth Information
References
Rare Rheumatology News |