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Disease Profile
Brucellosis
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
0
Age of onset
All ages
ICD-10
A23.0 A23.1 A23.2 A23.3 A23.8 A23.9
Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Not applicable
Other names (AKA)
Malta fever; Undulant fever; Rock fever;
Categories
Bacterial infections
Summary
Brucellosis is a bacterial infection that spreads from animals to people via unpasteurized dairy products or by exposure to contaminated animal products or infected animals.[1][2] Animals that are most commonly infected include sheep, cattle, goats, pigs, and dogs. Brucellosis can cause of range of signs and symptoms, some of which may persist or recur. Initial symptoms may include fever, sweats, malaise, anorexia, headache, fatigue, and/or pain in the muscles, joints, and/or back. Symptoms that may persist or recur include fevers,
Symptoms
This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
Medical Terms | Other Names |
Learn More:
HPO ID
|
---|---|---|
30%-79% of people have these symptoms | ||
Abnormality of hepatobiliary system physiology | 0025155 | |
Abnormality of the gastrointestinal tract | 0011024 | |
Low number of red blood cells or hemoglobin
|
0001903 | |
Anorexia | 0002039 | |
Arthralgia |
Joint pain
|
0002829 |
Asthenia | 0025406 | |
Elevated C-reactive |
0011227 | |
Elevated |
High ESR
|
0003565 |
Fatigue |
Tired
Tiredness
[ more ] |
0012378 |
Fever | 0001945 | |
Hepatomegaly |
Enlarged liver
|
0002240 |
Hyperhidrosis |
Excessive sweating
Increased sweating
Profuse sweating
Sweating
Sweating profusely
Sweating, increased
[ more ] |
0000975 |
Increased circulating IgG level | 0003237 | |
Leukopenia |
Decreased blood leukocyte number
Low white blood cell count
[ more ] |
0001882 |
Nausea | 0002018 | |
Septic |
0003095 | |
Splenomegaly |
Increased spleen size
|
0001744 |
Weight loss | 0001824 | |
5%-29% of people have these symptoms | ||
Abdominal pain |
Pain in stomach
Stomach pain
[ more ] |
0002027 |
Abnormality of bone marrow |
0005561 | |
Abnormality of the peripheral nervous system | 0410008 | |
Bronchitis | 0012387 | |
Chills | 0025143 | |
Cutaneous cyst | 0025245 | |
Depressivity |
Depression
|
0000716 |
Epididymitis | 0000031 | |
Erythematous papule | 0030350 | |
Failure to thrive |
Faltering weight
Weight faltering
[ more ] |
0001508 |
Glomerulonephritis | 0000099 | |
Granuloma | 0032252 | |
Headache |
Headaches
|
0002315 |
Hip osteoarthritis | 0008843 | |
Hypersplenism | 0001971 | |
Immunologic hypersensitivity | 0100326 | |
Increased circulating IgM level | 0003496 | |
Knee osteoarthritis | 0005086 | |
Leukocytosis |
Elevated white blood count
High white blood count
Increased blood leukocyte number
[ more ] |
0001974 |
Liver abscess | 0100523 | |
Lymphadenopathy |
Swollen lymph nodes
|
0002716 |
Orchitis |
Inflammation of testicles
|
0100796 |
Osteomyelitis |
Bone infection
|
0002754 |
0009830 | ||
Pleural effusion |
Fluid around lungs
|
0002202 |
Pneumonia | 0002090 | |
Premature birth |
Premature delivery of affected infants
Preterm delivery
[ more ] |
0001622 |
Purpura |
Red or purple spots on the skin
|
0000979 |
Rheumatoid factor positive | 0002923 | |
Sacroiliac arthritis | 0012317 | |
Small for gestational age |
Birth weight less than 10th percentile
Low birth weight
[ more ] |
0001518 |
Spontaneous abortion | 0005268 | |
Low platelet count
|
0001873 | |
Vomiting |
Throwing up
|
0002013 |
1%-4% of people have these symptoms | ||
Abnormal aortic valve morphology | 0001646 | |
Abnormal cranial nerve physiology | 0031910 | |
Anterior uveitis | 0012122 | |
Arteritis |
Inflammation of artery
|
0012089 |
Chorea | 0002072 | |
Chorioretinitis | 0012424 | |
Encephalitis |
Brain inflammation
|
0002383 |
Endocarditis | 0100584 | |
Intrarenal abscess | 0032620 | |
Lung abscess | 0025044 | |
Myocarditis |
Inflammation of heart muscle
|
0012819 |
Pericarditis |
Swelling or irritation of membrane around heart
|
0001701 |
Pulmonary granulomatosis | 0030250 | |
Thrombocytosis |
Increased number of platelets in blood
|
0001894 |
Thrombophlebitis | 0004418 | |
Transient ischemic attack |
Mini stroke
|
0002326 |
References
- Brucellosis. Centers for Disease Control and Prevention. November 12, 2012; https://www.cdc.gov/brucellosis/. Accessed 12/12/2014.
- Brucellosis. Mayo Clinic. January 2, 2014; https://www.mayoclinic.org/diseases-conditions/brucellosis/basics/definition/con-20028263. Accessed 12/12/2014.
- Wafa Al-Nassir. Brucellosis. Medscape Reference. March 10, 2014; https://emedicine.medscape.com/article/213430-overview. Accessed 12/12/2014.
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