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Disease Profile

Metaplastic carcinoma of the breast

Prevalence
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.

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US Estimated

Europe Estimated

Age of onset

Adult

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ICD-10

C50.0 C50.1 C50.2 C50.3 C50.4 C50.5 C50.6 C50.8

Inheritance

Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.

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Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.

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X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.

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X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.

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Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.

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Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.

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Not applicable

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Other names (AKA)

Metaplastic breast cancer

Categories

Female Reproductive Diseases; Rare Cancers

Summary

Metaplastic carcinoma of the breast is a rare form of breast cancer. The tumor cells differ in type from that of the typical ductal or lobular breast cancers. The cells look like skin cells or cells that make bone. Some women experience no early signs or symptoms, while others experience general symptoms of breast cancers, such as new breast lumps. Treatment of metaplastic carcinoma of the breast is similar to that of invasive ductal cancer.[1]

Organizations

Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.

Organizations Supporting this Disease

    Organizations Providing General Support

      Learn more

      These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.

      Where to Start

      • The Johns Hopkins Medicine Web site has an information page on metaplastic carcinoma of the breast. Click on the link to view the information page.
      • The Cancer.Net provides comprehensive information on this topic for patients and their families. Click on the link to visit Cancer.Net and view a description of metaplastic carcinoma of the breast. To view additional information, click on "Next >" which is located at the bottom of their Web pages.
      • The Stanford School of Medicine Web site provides technical information regarding the diagnosis of metaplastic carcinoma of the breast. Click on the link to view the information page.

        In-Depth Information

        • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
        • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
        • PubMed is a searchable database of medical literature and lists journal articles that discuss Metaplastic carcinoma of the breast. Click on the link to view a sample search on this topic.

          Selected Full-Text Journal Articles

            References

            1. What is breast cancer?. American Cancer Society. https://www.cancer.org/Cancer/BreastCancer/DetailedGuide/breast-cancer-what-is-breast-cancer. Accessed 6/21/2011.
            2. Smitt MC. . Metaplastic breast cancer. Clin Breast Cancer. 2003 Aug; 4(3):210-1; https://cigjournals.metapress.com/content/563q0180h65p7618/fulltext.pdf. Accessed 6/21/2011.
            3. Breast cancer Metaplastic: Risk factors. American Society of Clinical Oncology. https://www.cancer.net/patient/Cancer+Types/Breast+Cancer+-+Metaplastic?sectionTitle=Risk%20Factors. Accessed 6/21/2011.